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How Long Does LSD Stay in Your System?

October 25, 2025

Detection Times, Blotter Comparisons, and How 1S-LSD Compares to Other Substances

LSD, also known as lysergic acid diethylamide, is a powerful hallucinogenic compound that has fascinated researchers, psychonauts, and health professionals for decades. With the rise of legal LSD analogs like 1S-LSD1BS-LSD, and others, new questions are surfacing — especially around detection timeduration of effect, and how different blotter doses influence how long the substance stays in your body.

In this guide, we’ll explore:

  • Legal LSD analog insights (1S-LSD, 1BS-LSD)
  • How long LSD and its analogs remain detectable in the body
  • Differences between 80 µg and 150 µg blotters
  • Detection windows in urine, blood, saliva, and hair
  • How LSD compares to other common substances

How Long Is LSD Detectable in the Body?

Although the effects of LSD typically last between 6–12 hours, the compound or its metabolites can remain detectable in biological systems long after the experience ends. Here’s a general breakdown:

Test TypeDetection Time for LSD
Urine1–4 days
BloodUp to 12 hours
SalivaUp to 8–12 hours
HairUp to 90 days

Note: Detection time can vary based on dosefrequency of usemetabolismbody fat percentagehydration, and test sensitivity.

LSD analogs like 1S-LSD and 1BS-LSD are prodrugs, meaning they metabolize into LSD-25 once inside the body. Therefore, most standard drug tests that detect LSD metabolites (e.g., 2-oxo-3-hydroxy-LSD) may also detect these analogs indirectly — especially if using advanced chromatography methods.

That said, basic drug panels (like a 5-panel test) do not screen for LSD or its analogs.

Blotter & Pellet Comparisons: Potency and Duration

⚪ 1S-LSD – 80 µg Blotter

  • Onset: 30–60 minutes
  • Duration: 6–9 hours
  • Detection: 1–3 days in urine
  • Effect: Mild to moderate, often described as suitable for microdosing or first-time research

🔵 1BS-LSD – 150 µg Blotter

  • Onset: 45–75 minutes
  • Duration: 8–12 hours
  • Detection: 1–4 days
  • Effect: Stronger and more immersive, comparable to a full recreational dose of LSD-25

🟣 1S-LSD – 150 µg Pellet

  • Onset: 45–90 minutes
  • Duration: 8–12 hours
  • Detection: Up to 3 days
  • Effect: Similar to blotters, but some report slower absorption due to oral disintegration time

Conclusion: Higher microgram dosage = longer subjective experience + longer detection window.

LSD vs Other Substances: Detection Window Comparison

SubstanceUrine Detection WindowBloodSalivaHair
LSD1–4 daysUp to 12hUp to 12h90 days
THC (Cannabis)3–30+ days (chronic)1–2 daysUp to 24h90 days
Cocaine2–4 days1–2 days1–2 days90 days
MDMA (Ecstasy)1–3 days1–2 daysUp to 24h90 days
Psilocybin<24 hours<6h<12hLimited
1S-LSD / Analogs1–4 days8–12 hoursUp to 12h90 days

Can LSD Be Detected in Standard Drug Tests?

In general: No — most routine drug screenings (e.g. employment tests) do not include LSD or its analogs.

However, specialized tests (GC-MS or LC-MS) can detect it if specifically requested, particularly in clinical, forensic, or legal settings.

How to Minimize Detection Risk (For Researchers)

If you’re handling LSD analogs like 1S-LSD for research purposes and need to minimize detection in systems:

  • Use personal protective equipment (gloves, goggles, etc.)
  • Avoid skin contact or inhalation
  • Label and store substances securely
  • Dispose of materials according to lab protocols
  • Do not consume the substance (these compounds are not for human use)

Summary: LSD Detection – What You Should Know

CompoundDose FormDetection Time (Urine)Notes
1S-LSD80 µg Blotter1–3 daysMild dose, short detection
1BS-LSD150 µg Blotter1–4 daysStronger analog
1S-LSD150 µg Pellet2–3 daysSlower onset
LSD-25N/A1–4 daysControlled substance

LSD and its legal analogs like 1S-LSD and 1BS-LSD present exciting avenues for scientific research. While detection times vary, they generally don’t show up in standard drug tests, making them attractive for analytical labs working within legal frameworks.

Understanding blotter strengthchemical structure, and metabolism helps researchers choose the right compound while ensuring responsible handling and compliance.

If you’re sourcing legal LSD alternatives for research, ensure you’re using verified, lab-tested material — with clear documentation and transparent supplier practices.

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